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| An assay for immunoglobulines in the blood of mice treated with Lectranal® |
The objective of this research was to determine how the Lectranal® used to treat inflammatory processes affects the level of protective immunoglobulines in the blood.
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METHODS
The inflammatory process in mice was provoked through an intradermal application of Freund’s adjuvant. They were given the Lectranal® orally for the following 14 days, after which a blood sample was collected. The IgA, IgG and IgM immunoglobulines concentrations were determined using a spectrometric method.
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The treatment with Lectranal® significantly increases the concentration of the IgG immunoglobulines.
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CONCLUSION
The results confirm previous findings that Lectranal® diverts the immune response towards the Th1 response, which results in the increased production of IgG class immunoglobulines, which neutralizes the allergen by phagocytosis.
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AUTHORS
Hadžija M., Popović Hadžija M., Korolija M.
Ruđer Bošković Institute, Zagreb 2006
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