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An assay for immunoglobulines in the blood of mice treated with Lectranal®

The objective of this research was to determine how the Lectranal® used to treat inflammatory processes affects the level of protective immunoglobulines in the blood.

METHODS

The inflammatory process in mice was provoked through an intradermal application of Freund’s adjuvant. They were given the Lectranal® orally for the following 14 days, after which a blood sample was collected. The IgA, IgG and IgM immunoglobulines concentrations were determined using a spectrometric method.

RESULTS


The treatment with Lectranal® significantly increases the concentration of the IgG immunoglobulines.


CONCLUSION

The results confirm previous findings that Lectranal® diverts the immune response towards the Th1 response, which results in the increased production of IgG class immunoglobulines, which neutralizes the allergen by phagocytosis.

AUTHORS

Hadžija M., Popović Hadžija M., Korolija M.
Ruđer Bošković Institute, Zagreb 2006

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