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How does Lectranal® work
Animal gene studies suggests that Lectranal® aims specifically at the imbalance of the immune system that triggers the overproduction of substances that cause allergy symptoms.



Double effect
A change in relb gene activity is noted in Th1 cells. This could affect numerous reactions, which via IFN-gamma:
- shift the Th1/Th2 balance in favour of Th1: by recruiting them from Th0 and by the enhanced multiplication of Th1
- cause the proliferation of specific B-clone lymphocytes into plasma cells that produce IgG
Ikbkg gene activity and translocation of the NF-kB transcription factor is noted inB lymphocytes, which suggest:
- the formation of the clonal selection of specific B lymphocytes and the formation of memory cells, which then transform into plasma cells and produce IgG
The produced IgGs could enable the macrophages to opsonize and phagocytize the allergen, and to neutralize it without the appearance of a symptomatic reaction.
RELATED ARTICLES
EFFICACY AND SAFETY OF LECTRANAL® IN THE TREATMENT OF SEASONAL ALLERGIC RHINITIS SYMPTOMS
Preclinical toxicity study on Lectranal®
Lectranal® and intradermal inflammatory reactions
An assay for immunoglobulines in the blood of mice treated with Lectranal®
Lectranal®, inflammatory reaction, and gene expression in mouse spleen
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