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| Preclinical toxicity study on Lectranal® |
| To determine the safety profile of allergy-relieving ingredient Lectranal®, a multiple-dose, 28-day toxicity study was performed on mice. The study was perfomed at the Ruđer Bošković Institute in Zagreb according to OECD protocol 407. Since Lectranal® requires an enteric delivery, in this experiment it was administered either by gastric or enteric gavage at three different dosage levels. |
| No mortality, adverse reactions, or behavioral changes were observed in any of the groups. There was no significant weight change in any of the animals. Feed and water consumption were unchanged compared to the controls. Urinanalysis, haematology, and biochemistry results revealed no significant difference between the treated and control groups. No changes were revealed by necropsy and there was no difference in organ weight between the treated and control animals. Histology results were normal and similar to the controls. |
There were no toxicity effects of any kind as result of Lectranal® application. Taken together, these results show that Lectranal® has a good safety profile.
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| For the details download the report on the right. |
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