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Lectranal®, inflammatory reaction, and gene expression in mouse spleen
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The objective was to assess the genetic base of the anti-inflammatory effect of Lectranal® using the gene chip method on mouse spleen cells.

METHODS

The inflammatory allergic process was provoked by the subcutaneous application of an incomplete Freund’s adjuvant (FA). All the animals were divided into three groups, depending on whether they had been treated with Lectranal®, Astragalus extract, or calcium, which they had been receiving orally every day for a period of 14 days.
After 14 days of treatment, RNA was isolated from the mouse spleen cells for DNA analysis using microarray genome chip technology. GEArray Q series chips for mice, which cover the autoimmune and inflammatory processes in the system, were used.

RESULTS

The results of the analysis showed that Lectranal® acted on the genes that were involved in individual metabolic processes of the immune response as a result of the inflammatory stimulus. The genes whose activity significantly changed after the application of FA and returned to normal values, which equal the control values after the therapy with Lectranal®, belong to the following categories:
ADAPTOR PROTEINS
Fadd
Fadd
Irak2
Irak2
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